Last update
5/14/2026
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
9
We investigated whether higher levels of vitamin D could lower the risk of uterine fibroids, which are common benign tumors affecting women’s health. Using a robust two-sample Mendelian Randomization approach, we analyzed data from over 441,000 individuals.
Our findings suggest a significant link: elevated vitamin D levels appear to correlate with a reduced risk of developing fibroids. This could present new opportunities for clinical treatment. However, further exploration is essential to confirm these promising results.
Our findings suggest a significant link: elevated vitamin D levels appear to correlate with a reduced risk of developing fibroids. This could present new opportunities for clinical treatment. However, further exploration is essential to confirm these promising results.
Read More
8
Vitamin D reduces uterine fibroid size
We examined the potential benefits of vitamin D supplementation on uterine fibroids through a systematic review of randomized controlled trials. Analyzing five studies with over 500 participants, we found that vitamin D could significantly reduce the size of these fibroids.
Interestingly, longer supplementation periods of more than eight weeks showed even greater reductions in fibroid size. While vitamin D improved serum levels as well, further well-structured trials are necessary to explore its effects in greater detail.
Interestingly, longer supplementation periods of more than eight weeks showed even greater reductions in fibroid size. While vitamin D improved serum levels as well, further well-structured trials are necessary to explore its effects in greater detail.
Read More
8
Vitamin D may reduce fibroid recurrence
We explored whether vitamin D supplementation could help prevent the recurrence of uterine fibroids in women who had undergone surgery. In a well-conducted study, participants were randomly assigned to receive either vitamin D or a placebo for a year.
While we found that vitamin D reduced recurrence rates by 50% and decreased the size of fibroids, these results weren't statistically significant.
Overall, vitamin D shows promise in managing uterine fibroids, but more comprehensive studies are needed to confirm these findings.
While we found that vitamin D reduced recurrence rates by 50% and decreased the size of fibroids, these results weren't statistically significant.
Overall, vitamin D shows promise in managing uterine fibroids, but more comprehensive studies are needed to confirm these findings.
Read More
Most Useful Reviews
9
Vitamin D benefits
For adults, for prevention - 1 pc. daily. Normal vitamin D levels protect against colorectal cancer, depression, and rickets. Levels of 75-100 nmol/l (30-40 ng/ml) increase immunity and dental health. Vitamin D3 reduces the risk of pancreatic cancer and regulates calcium-phosphorus metabolism, influencing growth, bone density, and tissue formation. In women, it regulates the cycle, as deficiency is linked to PCOS, endometriosis, uterine fibroids, and cysts.
Read More
7.5
Relieves menstrual pain
The effect is positive and health-enhancing. Vitamin D2 mainly derives from plants, whilst D3 comes from animals. D3 is more effective in raising active vitamin D levels. I've read studies recommending women over 19 take 4000 IU of D3 daily, which can relieve menstrual pain, improve polycystic ovary syndrome, significantly reduce the size of uterine fibroids, and enhance vitamin D levels.
Read More
7.5
Aids in estrogen control
I’m increasing my vitamin D3 dosage to manage estrogen better. Previously, I only took 30 capsules a month. Now, I've upgraded to 120 capsules, taking two daily. I’ve noticed an improvement in recovering from an infection and I hope to reduce my fibroids as well. My periods have become lighter and less painful.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
- All Researches
9
We investigated whether higher levels of vitamin D could lower the risk of uterine fibroids, which are common benign tumors affecting women’s health. Using a robust two-sample Mendelian Randomization approach, we analyzed data from over 441,000 individuals.
Our findings suggest a significant link: elevated vitamin D levels appear to correlate with a reduced risk of developing fibroids. This could present new opportunities for clinical treatment. However, further exploration is essential to confirm these promising results.
Our findings suggest a significant link: elevated vitamin D levels appear to correlate with a reduced risk of developing fibroids. This could present new opportunities for clinical treatment. However, further exploration is essential to confirm these promising results.
Read More
8
Vitamin D reduces uterine fibroid size
We examined the potential benefits of vitamin D supplementation on uterine fibroids through a systematic review of randomized controlled trials. Analyzing five studies with over 500 participants, we found that vitamin D could significantly reduce the size of these fibroids.
Interestingly, longer supplementation periods of more than eight weeks showed even greater reductions in fibroid size. While vitamin D improved serum levels as well, further well-structured trials are necessary to explore its effects in greater detail.
Interestingly, longer supplementation periods of more than eight weeks showed even greater reductions in fibroid size. While vitamin D improved serum levels as well, further well-structured trials are necessary to explore its effects in greater detail.
Read More
8
Vitamin D shows surgical benefits
We investigated the effects of a treatment regimen that included vitamin D, along with other compounds, on uterine fibroids in women preparing for laparoscopic myomectomy.
Our study involved women aged 30 to 40, where one group received the supplement combination for three months while the control group did not receive any treatment.
Results showed significant improvements in surgical outcomes for those who took the supplements, such as shorter surgery times and less blood loss. However, our findings do not indicate that vitamin D alone is directly beneficial for uterine fibroids specifically.
Our study involved women aged 30 to 40, where one group received the supplement combination for three months while the control group did not receive any treatment.
Results showed significant improvements in surgical outcomes for those who took the supplements, such as shorter surgery times and less blood loss. However, our findings do not indicate that vitamin D alone is directly beneficial for uterine fibroids specifically.
Read More
8
We conducted a study to determine how vitamin D affects uterine fibroids in premenopausal women. Our evaluation involved 64 women with vitamin D deficiency, who were split into two groups: one receiving vitamin D supplements and the other not.
After three months, we found that vitamin D significantly reduced the size of the fibroids and improved symptoms like painful periods and heavy bleeding. However, it didn’t change blood flow to the fibroids. Overall, vitamin D shows promise as a safe and effective treatment for uterine fibroids.
After three months, we found that vitamin D significantly reduced the size of the fibroids and improved symptoms like painful periods and heavy bleeding. However, it didn’t change blood flow to the fibroids. Overall, vitamin D shows promise as a safe and effective treatment for uterine fibroids.
Read More
8
We evaluated how vitamin D might influence uterine fibroids, common tumors affecting many women. Our systematic review gathered results from various studies, highlighting that a decrease in vitamin D receptor levels occurs in fibroid cells.
We found that higher vitamin D levels correlated with fewer fibroids in a large group of women. Notably, four out of five clinical studies suggested that vitamin D treatment could slow the growth of fibroids. However, despite these promising signs, more rigorous clinical trials are necessary to confirm its effectiveness.
We found that higher vitamin D levels correlated with fewer fibroids in a large group of women. Notably, four out of five clinical studies suggested that vitamin D treatment could slow the growth of fibroids. However, despite these promising signs, more rigorous clinical trials are necessary to confirm its effectiveness.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Vitamin D benefits
For adults, for prevention - 1 pc. daily. Normal vitamin D levels protect against colorectal cancer, depression, and rickets. Levels of 75-100 nmol/l (30-40 ng/ml) increase immunity and dental health. Vitamin D3 reduces the risk of pancreatic cancer and regulates calcium-phosphorus metabolism, influencing growth, bone density, and tissue formation. In women, it regulates the cycle, as deficiency is linked to PCOS, endometriosis, uterine fibroids, and cysts.
Read More
7.5
Relieves menstrual pain
The effect is positive and health-enhancing. Vitamin D2 mainly derives from plants, whilst D3 comes from animals. D3 is more effective in raising active vitamin D levels. I've read studies recommending women over 19 take 4000 IU of D3 daily, which can relieve menstrual pain, improve polycystic ovary syndrome, significantly reduce the size of uterine fibroids, and enhance vitamin D levels.
Read More
7.5
Aids in estrogen control
I’m increasing my vitamin D3 dosage to manage estrogen better. Previously, I only took 30 capsules a month. Now, I've upgraded to 120 capsules, taking two daily. I’ve noticed an improvement in recovering from an infection and I hope to reduce my fibroids as well. My periods have become lighter and less painful.
Read More
6
Pain relief noted
I love these small, tasteless pills. I've been taking D3 to help decrease the size of my fibroids, and since starting, my cramps are not as severe. I am optimistic about continuing supplementation to see if my fibroids reduce in size, as I have already noticed less pain.
Read More
Frequently Asked Questions
6
Pain relief noted
I love these small, tasteless pills. I've been taking D3 to help decrease the size of my fibroids, and since starting, my cramps are not as severe. I am optimistic about continuing supplementation to see if my fibroids reduce in size, as I have already noticed less pain.
7.5
Aids in estrogen control
I’m increasing my vitamin D3 dosage to manage estrogen better. Previously, I only took 30 capsules a month. Now, I've upgraded to 120 capsules, taking two daily. I’ve noticed an improvement in recovering from an infection and I hope to reduce my fibroids as well. My periods have become lighter and less painful.
7.5
Relieves menstrual pain
The effect is positive and health-enhancing. Vitamin D2 mainly derives from plants, whilst D3 comes from animals. D3 is more effective in raising active vitamin D levels. I've read studies recommending women over 19 take 4000 IU of D3 daily, which can relieve menstrual pain, improve polycystic ovary syndrome, significantly reduce the size of uterine fibroids, and enhance vitamin D levels.
9
Vitamin D benefits
For adults, for prevention - 1 pc. daily. Normal vitamin D levels protect against colorectal cancer, depression, and rickets. Levels of 75-100 nmol/l (30-40 ng/ml) increase immunity and dental health. Vitamin D3 reduces the risk of pancreatic cancer and regulates calcium-phosphorus metabolism, influencing growth, bone density, and tissue formation. In women, it regulates the cycle, as deficiency is linked to PCOS, endometriosis, uterine fibroids, and cysts.
References
- Ivanova M, Soule A, Pudwell J, Bougie O. The Association of Vitamin D with Uterine Fibroids in Premenopausal Patients: A Systematic Review and Meta-Analysis. J Obstet Gynaecol Can. 2024;46:102632. 10.1016/j.jogc.2024.102632
- Alsharif SA, Baradwan S, Alshahrani MS, Khadawardi K, AlSghan R, et al. Effect of Oral Consumption of Vitamin D on Uterine Fibroids: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Nutr Cancer. 2024;76:226. 10.1080/01635581.2023.2288716
- Tinelli A, Panese G, Licchelli M, Morciano A, Pecorella G, et al. The impact of epigallocatechin gallate, vitamin D, and D-chiro-inositol on early surgical outcomes of laparoscopic myomectomy: a pilot study. Arch Gynecol Obstet. 2024;309:1021. 10.1007/s00404-023-07324-x
- Wang Q, Tian P, Sun W, Liu X, Yang X, et al. A Multimodal Ultrasound Observation Study on the Effect of Vitamin D on Uterine Fibroids in Non-menopausal Women. Curr Med Imaging. 2023. 10.2174/0115734056281479231030053817
- Simpson S, Pal L. Vitamin D and infertility. Curr Opin Obstet Gynecol. 2023;35:300. 10.1097/GCO.0000000000000887
- Guo W, Dai M, Zhong Z, Zhu S, Gong G, et al. The association between vitamin D and uterine fibroids: A mendelian randomization study. Front Genet. 2022;13:1013192. 10.3389/fgene.2022.1013192
- Harmon QE, Patchel SA, Denslow S, LaPorte F, Cooper T, et al. Vitamin D and uterine fibroid growth, incidence, and loss: a prospective ultrasound study. Fertil Steril. 2022;118:1127. 10.1016/j.fertnstert.2022.08.851
- Markowska A, Kurzawa P, Bednarek W, Gryboś A, Mardas M, et al. Immunohistochemical Expression of Vitamin D Receptor in Uterine Fibroids. Nutrients. 2022;14. 10.3390/nu14163371
- Combs A, Singh B, Nylander E, Islam MS, Nguyen HV, et al. A Systematic Review of Vitamin D and Fibroids: Pathophysiology, Prevention, and Treatment. Reprod Sci. 2023;30:1049. 10.1007/s43032-022-01011-z
- Cross CI, Driggers PH, McCarthy BE, Diab M, Brennan J, et al. A-kinase anchoring protein 13 interacts with the vitamin D receptor to alter vitamin D-dependent gene activation in uterine leiomyoma cells. F S Sci. 2021;2:303. 10.1016/j.xfss.2021.04.002
- Kumari R, Nath B, Gaikwad HS, Sharma M. Association between serum vitamin D level and uterine fibroid in premenopausal women in Indian population. Drug Discov Ther. 2022;16:8. 10.5582/ddt.2021.01019
- Vahdat M, Allahqoli L, Mirzaei H, Giovannucci E, Salehiniya H, et al. The effect of vitamin D on recurrence of uterine fibroids: A randomized, double-blind, placebo-controlled pilot study. Complement Ther Clin Pract. 2022;46:101536. 10.1016/j.ctcp.2022.101536
- Elkafas H, Badary O, Elmorsy E, Kamel R, Yang Q, et al. Endocrine-Disrupting Chemicals and Vitamin D Deficiency in the Pathogenesis of Uterine Fibroids. J Adv Pharm Res. 2021;5:260. 10.21608/aprh.2021.66748.1124
- Tunau KA, Garba JA, Panti AA, Shehu CE, Adamu AN, et al. Low plasma vitamin D as a predictor of uterine fibroids in a nigerian population. Niger Postgrad Med J. 2021;28:181. 10.4103/npmj.npmj_495_21
- Grandi G, Del Savio MC, Melotti C, Feliciello L, Facchinetti F. Vitamin D and green tea extracts for the treatment of uterine fibroids in late reproductive life: a pilot, prospective, daily-diary based study. Gynecol Endocrinol. 2022;38:63. 10.1080/09513590.2021.1991909
- Miriello D, Galanti F, Cignini P, Antonaci D, Schiavi MC, et al. Uterine fibroids treatment: do we have new valid alternative? Experiencing the combination of vitamin D plus epigallocatechin gallate in childbearing age affected women. Eur Rev Med Pharmacol Sci. 2021;25:2843. 10.26355/eurrev_202104_25537
